Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Random VDJ recombination early in T and B cell development enables the adaptive immune system to recognize a vast array of evolving pathogens via antigen receptors. However, the potential of such randomly generated TCRs and BCRs to recognize and respond to self-antigens requires layers of tolerance mechanisms to mitigate the risk of life-threatening autoimmunity. Since they were originally cloned more than three decades ago, the NR4A family of nuclear hormone receptors have been implicated in many critical aspects of immune tolerance, including negative selection of thymocytes, peripheral T cell tolerance, regulatory T cells (Treg), and most recently in peripheral B cell tolerance. In this review, we discuss important insights from many laboratories as well as our own group into the function and mechanisms by which this small class of primary response genes promotes self-tolerance and immune homeostasis to balance the need for host defense against the inherent risks posed by the adaptive immune system. © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.


Ryosuke Hiwa, Jeremy F Brooks, James L Mueller, Hailyn V Nielsen, Julie Zikherman. NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance. Immunological reviews. 2022 May;307(1):116-133

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 35174510

View Full Text