Mortality prediction of septic patients by blood caspase-8 levels.

Leonardo Lorente, María M Martín, Raquel Ortiz-López, Agustín F González-Rivero, Jacobo J Villacampa-Jiménez, Alejandro Jiménez, Antonia Pérez-Cejas

Diagnostic microbiology and infectious disease 2022 Apr

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We have not found data about blood caspase-8 concentrations (initiator caspase in the extrinsic pathway of apoptosis) during follow-up of sepsis and this was the objective of our study. We included septic patients. Serum caspase-8 concentrations were determined at days 1, 4, and 8 of sepsis diagnosis. We registered mortality at 30 days. Nonsurviving patients (n = 89) in respect to surviving patients (n = 160) showed higher serum caspase-8 levels at days 1 (P < 0.001), 4 (P <0.001), and 8 (P <0.001) of sepsis diagnosis. Serum caspase-8 levels on day 1, day 4, and day 8 had an area under curve for the prediction of 30-day mortality of 68% (60%-75%, P<0.001), 72% (62%-82%, P<0.001), and 81% (73%-90%, P<0.001). Thus, that blood caspase-8 concentrations at any time during the first week of sepsis were higher in non-survivor than in survivor patients and that were able to predict mortality were new findings in our study. Copyright © 2022 Elsevier Inc. All rights reserved.

Citation

Leonardo Lorente, María M Martín, Raquel Ortiz-López, Agustín F González-Rivero, Jacobo J Villacampa-Jiménez, Alejandro Jiménez, Antonia Pérez-Cejas. Mortality prediction of septic patients by blood caspase-8 levels. Diagnostic microbiology and infectious disease. 2022 Apr;102(4):115639