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Prolactin (PRL) is a pituitary hormone that has been typically related to lactogenesis in mammals. However, it has been described over 300 roles in the organism of vertebrae and its relationship with the central nervous system (CNS) is yet to be clarified. Mainly secreted by the pituitary gland, the source of prolactin in the CNS remains unclear, where some experiments suggest active transport via an unknown carrier or, on the contrary, PRL being synthesized on the brain. So far, it seems to be involved with neurogenesis, neuroprotection, maternal behavior and cognitive processes in the hippocampus and dentate gyrus, among other regions. Copyright © 2022 Elsevier Inc. All rights reserved.

Citation

Marta Carretero-Hernández, Leonardo Catalano-Iniesta, Enrique J Blanco, María José García-Barrado, José Carretero. Highlights regarding prolactin in the dentate gyrus and hippocampus. Vitamins and hormones. 2022;118:479-505

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PMID: 35180938

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