Structural insights into piRNA biogenesis.

Jin Zhang, Sizhuo Chen, Ke Liu

Biochimica et biophysica acta. Gene regulatory mechanisms 2022 Feb

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Discovered two decades ago, Piwi-interacting RNAs (piRNAs) play critical roles in gene regulation, transposon element repression, and antiviral defense. Dysregulation of piRNAs has been noted in diverse human diseases including cancers. Recently, extensive studies have revealed that many more proteins are involved in piRNA biogenesis. This review will summarize the recent progress in piRNA biogenesis and functions, especially the molecular mechanisms by which piRNA biogenesis-related proteins contribute to piRNA processing. Copyright © 2022 Elsevier B.V. All rights reserved.

Citation

Jin Zhang, Sizhuo Chen, Ke Liu. Structural insights into piRNA biogenesis. Biochimica et biophysica acta. Gene regulatory mechanisms. 2022 Feb;1865(2):194799