Correlation between lung function tests and peak oxygen consumption in post-TB lung disease.

BACKGROUND: After TB treatment, many patients have post-TB lung disease (PTLD), associated with increased mortality and morbidity. Nevertheless, relationships between lung function testing and exercise capacity in people with PTLD are poorly understood.METHODS: This single-centre study investigated the association between lung function testing and peak oxygen consumption (VO₂peak) and percentage-predicted VO₂peak (VO₂peak (%pred)) in adults with PTLD investigated for surgery.RESULTS: Eighty-two patients (52 males, 30 females) with a mean age of 43.2 years (SD 11.3) were included. Spirometric values of forced vital capacity (FVC) percentage predicted (%pred) and forced expiratory volume in 1 sec (FEV1) %pred suggested significant correlations with VO₂peak (%pred) (P < 0.001 and P < 0.001), whereas FEV1/FVC did not. Diffusing capacity for carbon monoxide (DLCO) %pred also correlated significantly with VO₂peak (%pred) (P = 0.002). However, the magnitude of all significant correlation coefficients were weak. No significant correlations for any plethysmographic values with VO₂peak (%pred) could be robustly concluded. Correlations with VO₂peak (ml/kg/min) for most physiological variables were less robust than for VO₂peak (%pred).CONCLUSIONS: Although statistically significant, the correlations between any measure of lung function and VO₂peak or VO₂peak (%pred) were weak, with only FVC correlation coefficient surpassing 0.50.

Citation

B D Curry, E van T Wout, E Maasdorp, A Nortje, E M Irusen, D Maree, C F N Koegelenberg, B W Allwood. Correlation between lung function tests and peak oxygen consumption in post-TB lung disease. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 2022 Mar 01;26(3):259-267

Mesh Tags

PMID: 35197166

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