Correlation Engine 2.0
Clear Search sequence regions

  • alginates (2)
  • bivalvia (1)
  • chitosan (8)
  • clam (4)
  • curcumin (6)
  • drug carriers (2)
  • fourier transform (1)
  • heparinoid (5)
  • mice (1)
  • phase (1)
  • polymer (2)
  • sodium (2)
  • strains (1)
  • Sizes of these terms reflect their relevance to your search.

    Chitosan/alginate nanoparticles (DG1-NPs and DG1/Cur-NPs) aiming to enhance the oral antithrombotic activity of clam heparinoid DG1 were prepared by ionotropic pre-gelation. The influence of parameters, such as the concentration of sodium alginate (SA), chitosan (CTS), CaCl2, clam heparinoid DG1, and curcumin (Cur), on the characteristics of the nanoparticles, were investigated. Results indicate that chitosan and alginate can be used as polymer matrices to encapsulate DG1, and nanoparticle characteristics depend on the preparation parameters. Nano-particles should be prepared using 0.6 mg/mL SA, 0.33 mg/mL CaCl2, 0.6 mg/mL CTS, 7.2 mg/mL DG1, and 0.24 mg/mL Cur under vigorous stirring to produce DG1-NPS and DG1/Cur-NPS with small size, high encapsulation efficiency, high loading capacity, and negative zeta potential from approximately -20 to 30 mV. Data from scanning electron microscopy, Fourier-transform infrared spectrometry, and differential scanning calorimetry analyses showed no chemical reaction between DG1, Cur, and the polymers; only physical mixing. Moreover, the drug was loaded in the amorphous phase within the nanoparticle matrix. In the acute pulmonary embolism murine model, DG1-NPs enhanced the oral antithrombotic activity of DG1, but DG1/Cur-NPs did not exhibit higher antithrombotic activity than DG1-NPs. Therefore, the chitosan/alginate nanoparticles enhanced the oral antithrombotic activity of DG1, but curcumin did not further enhance this effect.


    Guan-Lan Chen, Hong-Ying Cai, Jian-Ping Chen, Rui Li, Sai-Yi Zhong, Xue-Jing Jia, Xiao-Fei Liu, Bing-Bing Song. Chitosan/Alginate Nanoparticles for the Enhanced Oral Antithrombotic Activity of Clam Heparinoid from the Clam Coelomactra antiquata. Marine drugs. 2022 Feb 12;20(2)

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 35200665

    View Full Text