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An aqueous antiseptic containing "chlorhexidine digluconate/benzalkonium chloride/benzyl alcohol" (CBB) is widely used in France. The only previous documented study dealing with allergic contact dermatitis (ACD) to this antiseptic is one small case series in children. The French Vigilance Network for Dermatology and Allergy (REVIDAL-GERDA) has collected many cases in the last few years. To evaluate the clinical and sensitization profiles of patients diagnosed with ACD to CBB. We performed a retrospective study of patients with contact dermatitis to CBB and positive tests to CBB and/or at least one of its components. All patients had to be tested with all components of CBB. A total of 102 patients (71 adults and 31 children) were included. The lesions were extensive in 63% of patients and 55% had delayed time to diagnosis. CBB patch tests were positive in 93.8% of cases. The allergen was identified in 97% of patients, mainly benzyl alcohol in adults (81.7%) and chlorhexidine digluconate in children (54.8%). About 32.4% of the patients were sensitized to several components. CBB is a cause of ACD at all ages. The components of the antiseptic should be tested. The sensitization profile seems to be different between adults and children. © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.


Charlotte Beaumont, Anne-Sophie Darrigade, Annick Barbaud, Evelyne Collet, Nadia Raison-Peyron, Jean-Luc Bourrain, Haudrey Assier, Françoise Giordano-Labadie, Corina Bara-Passot, Brigitte Milpied, Florence Tétart, Pierre Armingaud, Florence Castelain, Lamia Benkalfate, Claire Boulard, Juliette Delaunay, Pascale Mathelier-Fusade, Catherine Pecquet, Pauline Pralong, Dominique Vital-Durand, Nathalie Genillier Foin, Marine-Alexia Lefèvre, Florence Hacard, Audrey Nosbaum, Justine Pasteur, Aude Valois, Martine Vigan, Marie-Christine Ferrier le Bouëdec, REVIDAL-GERDA Network. Multiple cases of sensitization to an antiseptic containing chlorhexidine digluconate/benzalkonium chloride/benzyl alcohol with different profiles of sensitization in adults and children. Contact dermatitis. 2022 Jul;87(1):62-70

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PMID: 35213760

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