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Fingolimod treatment has been associated with opportunistic infections, most notably PML and cryptococcal meningitis. There are rare reports of other infections like molluscum contagiosum which are typically associated with impaired cellular immunity as seen in AIDS. Upon review of our multiple sclerosis patient database, we identified eight patients undergoing fingolimod treatment who developed molluscum contagiosum infections. We suspect that this association is a class effect and may also be observed with other S1P receptor modulators. While molluscum contagiosum infection is not life-threatening, it can be extremely distressing for patients, and resolution may require discontinuation of fingolimod. Copyright © 2021 Elsevier B.V. All rights reserved.


Sabine Schneider, David Do, Ryan Fuller, Joseph R Berger. Molluscum contagiosum in the setting of Fingolimod: The experience at one institution. Multiple sclerosis and related disorders. 2022 Feb;58:103419

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PMID: 35216791

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