Recent advances in chemical synthesis, biocatalysis, and biological evaluation of diosgenin derivatives - A review.

Ruolan Fan, Weishen He, Yong Fan, Wen Xu, Wei Xu, Guohong Yan, Shaohua Xu

Steroids 2022 Apr

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Extracting organic compounds from plants and developing derivatives are essential methods for drug discovery. Diosgenin, extracted from Dioscoreaceae plants, is a type of spirostan steroid with various biological effects, including anti-inflammation, neuro-protection, and apoptosis-induction. Many researchers committed their work to the chemical semi-synthesis of diosgenin derivatives to improve diosgenin's therapeutic bioavailability and expand its range of applications in disease treatment and prevention. Biotransformation, a mild whole-cell biocatalysis method, also made crucial contributions to the structural diversity of diosgenin analogs in recent years. Although the structural modification of diosgenin has made significant progress, it lacks a comprehensive review. Here, we review the chemical modification and biotransformation of diosgenin along with the biological evaluation of diosgenin derivatives to provide a reference for the structural modification strategy and pharmaceutical application of diosgenin derivatives. Copyright © 2022 Elsevier Inc. All rights reserved.

Citation

Ruolan Fan, Weishen He, Yong Fan, Wen Xu, Wei Xu, Guohong Yan, Shaohua Xu. Recent advances in chemical synthesis, biocatalysis, and biological evaluation of diosgenin derivatives - A review. Steroids. 2022 Apr;180:108991