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One new phenylpropanoid schineolignin D (1), one new sesquiterpene (-)-(7S,10S)-3,11,12,13-tetrahydroxycalamenene (2), one new quinic acid 4-(E)-O-coumaroylquinic acid ethyl ester (3), and seven known compounds 4-10 were separated from the roots of Schisandra chinensis. The chemical structures of all compounds were characterized by NMR spectroscopic experiments. All compounds were assessed for their neuroprotective effects on PC12 cell lines induced by H2 O2 . Compounds 1, 3-4, and 7 showed statistically significant neuroprotective activities with the negative control group at 12.5 μM. © 2022 Wiley-VHCA AG, Zurich, Switzerland.


Zi Qi Peng, Yan Liu, Si Yi Wang, Yi Kai Jiang, Xiao Mao Li, Xiao Hui Rong, Ye Sun, Juan Pan, Wei Guan, Adnan Mohammed Algradi, Hai Xue Kuang, Bing You Yang. Chemical Constituents of the Roots of Schisandra chinensis. Chemistry & biodiversity. 2022 Apr;19(4):e202100962

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PMID: 35218144

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