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Understanding physiologic water balance and homeostasis mechanisms in the neonate is critical for clinicians in the NICU as pathologic fluid accumulation increases the risk for morbidity and mortality. In addition, once this process occurs, treatment is limited. In this review, we will cover fluid homeostasis in the neonate, explain the implications of prematurity on this process, discuss the complexity of fluid accumulation and the development of fluid overload, identify mitigation strategies, and review treatment options. Copyright © 2022 by the American Academy of Pediatrics.


Cara Slagle, Katja M Gist, Michelle C Starr, Trina S Hemmelgarn, Stuart L Goldstein, Alison L Kent. Fluid Homeostasis and Diuretic Therapy in the Neonate. NeoReviews. 2022 Mar 01;23(3):e189-e204

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PMID: 35229135

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