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In a recent study, Tracy, Madero-Pérez, Swaney, et al. observed that Tau interacts with mitochondrial and presynaptic vesicle proteins in human iPSC-derived neurons. Tau with mutations that cause neurodegeneration has decreased mitochondrial interactions. This elegant interactome mapping with supporting human brain data paves the way to a better understanding of Tau pathology and future Tau-directed therapeutics. Crown Copyright © 2022. Published by Elsevier Ltd. All rights reserved.


Declan King, Tara L Spires-Jones. Tau talk - synaptic and mitochondrial proteins interact with Tau in human neurons. Trends in neurosciences. 2022 May;45(5):339-341

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PMID: 35232606

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