IL-34 and coronary heart disease complicated with diabetes mellitus.

Huiqing Liu, Fengbiao Jin, Qinglian Li, Yu Gao, Xiaoteng Liu, Ruitian Hou

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2021 Dec 28

filter terms:

Coronary heart disease and diabetes mellitus are closely related to chronic low-grade inflammation. Interleukin-34 (IL-34) is a new member of the interleukin family discovered in recent years. It is involved in the pathophysiological process of mononuclear phagocyte system mainly via binding to colony stimulating factor-1 receptor, and it is closely related to inflammatory and autoimmune diseases. IL-34 is highly expressed in patients with coronary heart disease or diabetes mellitus. IL-34 induces atherosclerosis and insulin resistance through multiple pro-inflammatory actions, ultimately leading to the occurrence and development of coronary heart disease, type 2 diabetes, and their comorbidities.

Citation

Huiqing Liu, Fengbiao Jin, Qinglian Li, Yu Gao, Xiaoteng Liu, Ruitian Hou. IL-34 and coronary heart disease complicated with diabetes mellitus. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2021 Dec 28;46(12):1409-1414