Molecular Fluorescent Probes for Liver Tumor Imaging.

Qian Liu, Jia Huang, Longwei He, Xuefeng Yang, Lin Yuan, Dan Cheng

Chemistry, an Asian journal 2022 Apr 14

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Liver cancer is a malignant tumor with both high morbidity and mortality. The traditional treatment method is mainly based on hepatectomy for liver tumor. However, it is difficult to accurately distinguish the tumor tissue and its boundary with the naked eye and palpation, leading to an ambiguous resection result, finally causing high recurrence of liver cancer. Molecular fluorescent probes possessing numerous advantages, such as non-invasiveness, high sensitivity, and real-time imaging, have been extensively studied in liver cancer imaging and therapy. In this review, we briefly introduce the recent developments of always-on and activatable fluorescent probes in liver cancer imaging and therapy. Future potential challenges of the fluorescent probes for liver tumor imaging are also discussed. We expect that this review would improve the fluorescent probes development for real clinical application of liver cancer disease. © 2022 Wiley-VCH GmbH.

Citation

Qian Liu, Jia Huang, Longwei He, Xuefeng Yang, Lin Yuan, Dan Cheng. Molecular Fluorescent Probes for Liver Tumor Imaging. Chemistry, an Asian journal. 2022 Apr 14;17(8):e202200091