Human defensin-inspired discovery of peptidomimetic antibiotics.

Gan Luo, Jue Zhang, HanBin Wang, YaQi Sun, BaoLi Cheng, ZhiPeng Xu, Yan Zhang, Hui Li, WuYuan Lu, Elizabeta Nemeth, Tomas Ganz, XiangMing Fang

Proceedings of the National Academy of Sciences of the United States of America 2022 Mar 08

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SignificanceWe report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, the lead compound is efficacious in vitro and in vivo against bacteria with highly inducible antibiotic resistance, promising a useful therapeutic agent for the treatment of infections caused by antibiotic-resistant bacteria.

Citation

Gan Luo, Jue Zhang, HanBin Wang, YaQi Sun, BaoLi Cheng, ZhiPeng Xu, Yan Zhang, Hui Li, WuYuan Lu, Elizabeta Nemeth, Tomas Ganz, XiangMing Fang. Human defensin-inspired discovery of peptidomimetic antibiotics. Proceedings of the National Academy of Sciences of the United States of America. 2022 Mar 08;119(10):e2117283119