Expanding Roles of Noncoding RNAs in the Pathogenesis of Systemic Lupus Erythematosus.

Yiwei Shen, Bo Qu, Nan Shen

Current rheumatology reports 2022 Mar

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The exact pathogenesis of systemic lupus erythematosus (SLE) remains unclear. Accumulating finds have indicated the roles of the non-coding RNAs (ncRNAs) acting as novel epigenetic regulatory elements in the dysfunction of the immune system in SLE. This review will introduce recent studies on how ncRNAs are involved in the development of SLE. Recent advances in ncRNAs biology have greatly expanded our understanding of epigenetic regulation of immune responses and inflammation, and increasing evidence suggests ncRNAs are important players in SLE development. Identifications of abnormal expression patterns of ncRNAs and relevant biological impacts in lupus patients have revealed their potential as novel biomarkers and therapeutic targets for SLE. The dysregulation of ncRNAs contributes to the immunopathogenesis of SLE. Clarifying the functions and mechanisms of SLE-associated ncRNAs provides new opportunities for disease biomarkers and targeted therapies. © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Citation

Yiwei Shen, Bo Qu, Nan Shen. Expanding Roles of Noncoding RNAs in the Pathogenesis of Systemic Lupus Erythematosus. Current rheumatology reports. 2022 Mar;24(3):64-75