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    Four new tricyclic macrolides, named shikinefragalides A (1), B (2), C (3) and D (4), were isolated by physicochemical (PC) screening from a static culture material of Stachybotryaceae sp. FKI-9632. Their structures were elucidated as new analogs of colletofragarones by MS and NMR analyses. Compounds 1 and 2 showed weak antimalarial activity and cytotoxicity. © 2022. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.

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    Rima Koike, Yoshihiro Watanabe, Kazuho Kato, Yudai Mikasa, Kota Shimizu, Kenichi Nonaka, Masako Honsho, Takuya Suga, Rei Hokari, Aki Ishiyama, Yukihiro Asami, Masato Iwatsuki. Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632. The Journal of antibiotics. 2022 Apr;75(4):199-206

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    PMID: 35241792

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