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    Four new tricyclic macrolides, named shikinefragalides A (1), B (2), C (3) and D (4), were isolated by physicochemical (PC) screening from a static culture material of Stachybotryaceae sp. FKI-9632. Their structures were elucidated as new analogs of colletofragarones by MS and NMR analyses. Compounds 1 and 2 showed weak antimalarial activity and cytotoxicity. © 2022. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.


    Rima Koike, Yoshihiro Watanabe, Kazuho Kato, Yudai Mikasa, Kota Shimizu, Kenichi Nonaka, Masako Honsho, Takuya Suga, Rei Hokari, Aki Ishiyama, Yukihiro Asami, Masato Iwatsuki. Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632. The Journal of antibiotics. 2022 Apr;75(4):199-206

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    PMID: 35241792

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