Insulin and cancer: a tangled web.

For a century, since the pioneering work of Otto Warburg, the interwoven relationship between metabolism and cancer has been appreciated. More recently, with obesity rates rising in the U.S. and worldwide, epidemiologic evidence has supported a link between obesity and cancer. A substantial body of work seeks to mechanistically unpack the association between obesity, altered metabolism, and cancer. Without question, these relationships are multifactorial and cannot be distilled to a single obesity- and metabolism-altering hormone, substrate, or factor. However, it is important to understand the hormone-specific associations between metabolism and cancer. Here, we review the links between obesity, metabolic dysregulation, insulin, and cancer, with an emphasis on current investigational metabolic adjuncts to standard-of-care cancer treatment. © 2022 The Author(s).

Citation

Brooks P Leitner, Stephan Siebel, Ngozi D Akingbesote, Xinyi Zhang, Rachel J Perry. Insulin and cancer: a tangled web. The Biochemical journal. 2022 Mar 18;479(5):583-607

Mesh Tags

Substances

PMID: 35244142

search → result