Chemokine receptor CCR1: new target for asthma therapy.

A recent study shows that chemokine receptor 1 (CCR1) plays a role in eosinophilic inflammation and that its ligand CCL15 is increased in asthmatic eosinophils (Du et al.). A companion study reports that N-truncated forms of CCL15 generated by tissue proteases induce biased CCR1 signaling (Shao et al.). These insights may provide the basis for the generation of more effective CCR antagonists as an oral therapy for asthma. Copyright © 2022 Elsevier Ltd. All rights reserved.

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Peter J Barnes. Chemokine receptor CCR1: new target for asthma therapy. Trends in pharmacological sciences. 2022 Jul;43(7):539-541

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PMID: 35246315

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