Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids.

Irina Smirnova, Anastasiya Petrova, Alexander Lobov, El'za Minnibaeva, Thao Tran Thi Phoung, Loc Tran Van, Myint Myint Khine, Iana Esaulkova, Alexander Slita, Vladimir Zarubaev, Oxana Kazakova

The Journal of antibiotics 2022 May

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A series of lupane-, oleanane- and dammarane-based triterpenoids with 3β-amino, A-ring azepano- and 3,4-seco-fragments has been synthesized and evaluated for antiviral activity against influenza A(H1N1) virus. It was found that azepanodipterocarpol 8 and 3β-amino-28-oxoallobetulin 11 showed antiviral activity with IC50 1.1 and 2.6 μg ml-1, and selectivity index of 19 and 10, respectively. © 2022. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.

Citation

Irina Smirnova, Anastasiya Petrova, Alexander Lobov, El'za Minnibaeva, Thao Tran Thi Phoung, Loc Tran Van, Myint Myint Khine, Iana Esaulkova, Alexander Slita, Vladimir Zarubaev, Oxana Kazakova. Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids. The Journal of antibiotics. 2022 May;75(5):258-267