Correlation Engine 2.0
Clear Search sequence regions

  • apoptosis (1)
  • dermal (2)
  • diseases and (1)
  • hair (9)
  • hair growth (1)
  • mammals (2)
  • mirnas (2)
  • mirnas (2)
  • regulates (1)
  • regulates genes (1)
  • stem cell (1)
  • WIF1 (1)
  • Wnt (5)
  • wool (1)
  • β catenin (3)
  • Sizes of these terms reflect their relevance to your search.

    Exosomal miRNAs are verified critical biomarkers, which participate in several biological processes. The growth and development of the hair follicle (HF) are typically controlled by the exosomal miRNAs via cell-to-cell communication. This study identified a high expression of miR-181a-5p in the low-passage DPC-Exos (exosomes derived from dermal papilla cell), revealing the transportation patterns of the DPC-Exos-derived miR-181a-5p entering the HFSC (hair follicle stem cell). The exosomal miR-181a-5p activates the Wnt/β-catenin signaling pathway by targeting the Wnt inhibitor WIF1 and thereby regulates the proteins and genes related to HF growth and development. Moreover, the exosomal miR-181a-5p was found to suppress the HFSC apoptosis but promoted the HFSC proliferation. The in vitro culture of the HF organ revealed that the exosomal miR-181a-5p possesses a positive role in hair growth. Collectively, the exosomal miR-181a-5p affects the HF growth and development through the Wnt/β-catenin signaling pathway. The exosomal miR-181a-5p might, therefore, act as the novel biomarker and therapeutic target for treating hair-related diseases and wool production in mammals. Copyright © 2022 Elsevier B.V. All rights reserved.


    Bohao Zhao, Jiali Li, Xiyu Zhang, Yingying Dai, Naisu Yang, Zhiyuan Bao, Yang Chen, Xinsheng Wu. Exosomal miRNA-181a-5p from the cells of the hair follicle dermal papilla promotes the hair follicle growth and development via the Wnt/β-catenin signaling pathway. International journal of biological macromolecules. 2022 May 15;207:110-120

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 35248611

    View Full Text