Fibroblast growth factor-23 as a biomarker of adverse outcomes in patients with coronary artery disease: a meta-analysis.

Shizhen Zheng, Chao Wang, Hao Yan, Min Xu, Yuejun Du

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2022 Jun

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Fibroblast growth factor-23 (FGF-23) level has been linked the adverse outcomes in patients with coronary artery disease (CAD). The purpose of this meta-analysis was to assess the predictive value of blood FGF-23 levels in CAD patients. Two authors comprehensively searched PubMed and Embase until 20 August 2021 to identify studies investigating the association of FGF-23 level with adverse outcomes in CAD patients. Outcomes of interest were major adverse cardiovascular events (MACEs), cardiovascular or all-cause mortality. Eight studies with 16,702 patients with CAD were identified. Pooled results showed that elevated FGF-23 level was associated with a higher risk of MACEs (risk ratio [RR] 1.56; 95% confidence intervals [CI] 1.32-1.84), cardiovascular mortality (RR 1.99; 95% CI 1.38-2.86), and all-cause mortality (RR 1.95; 95% CI 1.67-2.27) after adjusted confounding factors. In addition, per doubling increase in the FGD-23 level was associated with a 24% higher risk of MACEs. Each standard deviation increase in the FGD-23 level conferred a 36% higher risk of cardiovascular mortality. Elevated blood FGF-23 level is associated with a higher risk of MACEs, cardiovascular or all-cause mortality in patients with CAD, even after adjustment for renal function. Blood FGF-23 level may provide important predictive information in CAD patients.

Citation

Shizhen Zheng, Chao Wang, Hao Yan, Min Xu, Yuejun Du. Fibroblast growth factor-23 as a biomarker of adverse outcomes in patients with coronary artery disease: a meta-analysis. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2022 Jun;27(4):299-305