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    SignificanceDespite the identification of neural circuits and circulating hormones in olfactory regulation, the peripheral targets for olfactory modulation remain relatively unexplored. Here we show that dopamine D2 receptor (DRD2) is expressed in the cilia and somata of mature olfactory sensory neurons (OSNs), while nasal dopamine (DA) is mainly released from the sympathetic nerve terminals, which innervate the mouse olfactory mucosa (OM). We further demonstrate that DA-DRD2 signaling in the nose plays important roles in regulating olfactory function using genetic and pharmacological approaches. Moreover, the local DA synthesis in mouse OM is reduced during hunger, which contributes to starvation-induced olfactory enhancement. Altogether, we demonstrate that nasal DA and DRD2 receptor can serve as the potential peripheral targets for olfactory modulation.


    Hai-Qian Zhou, Liu-Jing Zhuang, Hong-Qiang Bao, Sheng-Ju Li, Feng-Yan Dai, Ping Wang, Qian Li, Dong-Min Yin. Olfactory regulation by dopamine and DRD2 receptor in the nose. Proceedings of the National Academy of Sciences of the United States of America. 2022 Mar 15;119(11):e2118570119

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    PMID: 35263227

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