Identification of multiple TAR DNA binding protein retropseudogene lineages during the evolution of primates.

Juan C Opazo, Kattina Zavala, Luis Vargas-Chacoff, Francisco J Morera, Gonzalo A Mardones

Scientific reports 2022 Mar 09

filter terms:

anthropoids (1)

cebus (1)

madagascar (1)

primates (3)

species (1)

species specificity (1)

squirrel (1)

tarsier (1)

Sizes of these terms reflect their relevance to your search.

The TAR DNA Binding Protein (TARDBP) gene has become relevant after the discovery of its several pathogenic mutations. The lack of evolutionary history is in contrast to the amount of studies found in the literature. This study investigated the evolutionary dynamics associated with the retrotransposition of the TARDBP gene in primates. We identified novel retropseudogenes that likely originated in the ancestors of anthropoids, catarrhines, and lemuriformes, i.e. the strepsirrhine clade that inhabit Madagascar. We also found species-specific retropseudogenes in the Philippine tarsier, Bolivian squirrel monkey, capuchin monkey and vervet. The identification of a retropseudocopy of the TARDBP gene overlapping a lncRNA that is potentially expressed opens a new avenue to investigate TARDBP gene regulation, especially in the context of TARDBP associated pathologies. © 2022. The Author(s).

Citation

Juan C Opazo, Kattina Zavala, Luis Vargas-Chacoff, Francisco J Morera, Gonzalo A Mardones. Identification of multiple TAR DNA binding protein retropseudogene lineages during the evolution of primates. Scientific reports. 2022 Mar 09;12(1):3823