Application of β-Glucosidase in a Biphasic System for the Efficient Conversion of Polydatin to Resveratrol.

Jie Zhou, Meng Liang, Yu Lin, Hao Pang, Yutuo Wei, Ribo Huang, Liqin Du

Molecules (Basel, Switzerland) 2022 Feb 23

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Resveratrol, an ingredient of traditional Chinese medicine, has beneficial effects on human health and huge potential for application in modern medicine. Polydatin is extracted from plants and then deglycosylated into resveratrol; enzymatic methods are preferred for this reaction. In this study, a β-D-glucosidase from Sphingomonas showed high efficiency in transforming polydatin into resveratrol and was tolerant toward organic solvents. Applying this enzyme in a biphasic transformation system resulted in 95.3% conversion of 20% concentration crude polydatin to resveratrol in 4 h. We thus report a new method for high-efficiency, clean production of resveratrol.

Citation

Jie Zhou, Meng Liang, Yu Lin, Hao Pang, Yutuo Wei, Ribo Huang, Liqin Du. Application of β-Glucosidase in a Biphasic System for the Efficient Conversion of Polydatin to Resveratrol. Molecules (Basel, Switzerland). 2022 Feb 23;27(5)