CFTR, Cell Junctions and the Cytoskeleton.

Ines Pankonien, Margarida C Quaresma, Cláudia S Rodrigues, Margarida D Amaral

International journal of molecular sciences 2022 Feb 28

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The multi-organ disease cystic fibrosis (CF) is caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) protein, a cAMP regulated chloride (Cl-) and bicarbonate (HCO3-) ion channel expressed at the apical plasma membrane (PM) of epithelial cells. Reduced CFTR protein results in decreased Cl- secretion and excessive sodium reabsorption in epithelial cells, which consequently leads to epithelial dehydration and the accumulation of thick mucus within the affected organs, such as the lungs, pancreas, gastrointestinal (GI) tract, reproductive system and sweat glands. However, CFTR has been implicated in other functions besides transporting ions across epithelia. The rising number of references concerning its association to actin cytoskeleton organization, epithelial cell junctions and extracellular matrix (ECM) proteins suggests a role in the formation and maintenance of epithelial apical basolateral polarity. This review will focus on recent literature (the last 10 years) substantiating the role of CFTR in cell junction formation and actin cytoskeleton organization with its connection to the ECM.

Citation

Ines Pankonien, Margarida C Quaresma, Cláudia S Rodrigues, Margarida D Amaral. CFTR, Cell Junctions and the Cytoskeleton. International journal of molecular sciences. 2022 Feb 28;23(5)