Artificial Egg Activation Using Calcium Ionophore.

Ahmed Attia, Cara Nicholson, Sarah J Martins da Silva

Seminars in reproductive medicine 2021 Nov

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Artificial oocyte activation, most commonly using calcium ionophore, is a treatment add-on utilized to avoid recurrence of abnormally low or total failed fertilization following in vitro fertilization/intracytoplasmic sperm injection. It aims to modify defective physiological processes, specifically calcium-mediated cell signaling that are critical to events required for fertilization. Routine application of artificial oocyte activation is neither required nor recommended; however, it represents an invaluable intervention for a subgroup of patients affected by sperm-related oocyte activation deficiency. Thieme. All rights reserved.

Citation

Ahmed Attia, Cara Nicholson, Sarah J Martins da Silva. Artificial Egg Activation Using Calcium Ionophore. Seminars in reproductive medicine. 2021 Nov;39(5-06):e5-e11