Discovery of polypyridyl iridium(III) complexes as potent agents against resistant Candida albicans.

Chen Fu, Qian Lv, Jing Fan, Shiming Wu, Ming Lei, Xing Zhang, Xiaorong Li, Wei Zhou, Yang Yu, Wenshan Ren, Chengzhi Zhao, Guojian Liao

European journal of medicinal chemistry 2022 Apr 05

filter terms:

The increasing emergence and spread of drug resistant Candida albicans represent a serious challenge for effective treatment and call for the development of new therapeutic options. To address this need, we synthesized a series of polypyridyl iridium(III) complexes and studied their antimicrobial activities. Herein, one lead iridium(III) complex Ir-3 [(ptpy)2Ir(dppz)]PF6, with ptpy = 2-(p-tolyl)pyridine and dppz = dipyrido[3,2-a:2',3'-c]phenazine, exhibited potent and broad-spectrum antifungal activities against drug-resistant pathogens and low hemolytic activity toward mammalian cells. Furthermore, Ir-3 showed low tendency to induce resistance, displayed biofilm inhibition and eradication activities. Significantly, Ir-3 exhibited potent in vivo antifungal activity in a murine model of disseminated candidiasis. This study may pave the way for the development of novel antifungal agent based upon polypyridyl iridium(III) complex to combat antifungal resistance. Copyright © 2022 Elsevier Masson SAS. All rights reserved.

Citation

Chen Fu, Qian Lv, Jing Fan, Shiming Wu, Ming Lei, Xing Zhang, Xiaorong Li, Wei Zhou, Yang Yu, Wenshan Ren, Chengzhi Zhao, Guojian Liao. Discovery of polypyridyl iridium(III) complexes as potent agents against resistant Candida albicans. European journal of medicinal chemistry. 2022 Apr 05;233:114250