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Three new ursane-type triterpenoids, 3-oxours-12-en-20, 28-olide (1), 3β-hydroxyurs-12-en-20, 28-olide (2) and 3β-hydroxyurs-11, 13(18)-dien-20, 28-olide (3), were isolated from a potent anti-inflammatory and antibacterial fraction of the ethanolic extract of Rosmarinus officinalis. Their structures were elucidated by a combination of extensive 1D- and 2D-NMR experiments, MS data and comparisons with literature reports. Compounds 1-3 exhibited significantly inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages, but no antibacterial activity was found at a concentration of 128 μg·mL-1. Copyright © 2022 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.


Xiang-Jian Zhong, Na Zhou, Xin Wang, Jin-Jie Li, Hui Ma, Yue Jiao, Jia-Hui Xu, Peng-Cheng Lin, Xiao-Ya Shang. Three new ursane-type triterpenoids from Rosmarinus officinalis and their biological activities. Chinese journal of natural medicines. 2022 Feb;20(2):155-160

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PMID: 35279243

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