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Both peripherally inserted central catheters (PICCs) and implanted port catheters (PORTs) are commonly used for the delivery of immunochemotherapy. We compared the safety of the two types of devices in a homogeneous and monocentric population of diffuse large B-cell lymphoma (DLBCL) patients who were treated with first-line immunochemotherapy by evaluating the numbers of catheter-related venous thromboses (VTs) and infections that occurred in the six months after implantation according to the type of device. Using a propensity score, the adjusted relative risk (ARR) between the type of catheter and the occurrence of catheter-related complications (infection and/or VT) of interest was retrospectively determined. 479 patients were enrolled (266 PORTs/213 PICCs), and 26 VTs (5.4%) and 30 infections (6.3%) were identified in the period following PICC/PORT implantation. The adjusted relative risk (ARR) of catheter-related complications (infection and/or VT) according to the type of device was 2.6 (95% CI =1.3-5.9, p = .0075). This risk increase associated with the PICC device was significant for both infections (ARR = 3.2; 95% CI = 1.3-10.9) and thrombosis (ARR = 4; 95% CI = 1.5-11.6). Our study supports the preferential use of PORTs for the first line of treatment for DLBCL patients. © 2022 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd.


Juliette Pénichoux, Julien Rio, Leila Kammoun, Thomas Vermeulin, Louis-Ferdinand Pepin, Vincent Camus, Sydney Dubois, Florian Bouclet, Mustafa Alani, Nathalie Contentin, Stéphane Leprêtre, Aspasia Stamatoullas, Hélène Lanic, Emilie Lemasle, Anne-Lise Ménard, Pascal Lenain, Marie Gilles-Baray, Dragos Georgescu, Florian Clatot, Hervé Tilly, Fabrice Jardin. Retrospective analysis of the safety of peripherally inserted catheters versus implanted port catheters during first-line treatment for patients with diffuse large B-cell lymphoma. European journal of haematology. 2022 Jul;109(1):41-49

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PMID: 35285085

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