Correlation Engine 2.0
Clear Search sequence regions

filter terms:
Sizes of these terms reflect their relevance to your search.

The effectiveness of any proteomics database search depends on the theoretical candidate information contained in the protein database. Unfortunately, candidate entries from protein databases such as UniProt rarely contain all the post-translational modifications (PTMs), disulfide bonds, or endogenous cleavages of interest to researchers. These omissions can limit discovery of novel and biologically important proteoforms. Conversely, searching for a specific proteoform becomes a computationally difficult task for heavily modified proteins. Both situations require updates to the database through user-annotated entries. Unfortunately, manually creating properly formatted UniProt Extensible Markup Language (XML) files is tedious and prone to errors. ProSight Annotator solves these issues by providing a graphical interface for adding user-defined features to UniProt-formatted XML files for better informed proteoform searches. It can be downloaded from © 2022 Wiley-VCH GmbH.


Joseph B Greer, Bryan P Early, Kenneth R Durbin, Steven M Patrie, Paul M Thomas, Neil L Kelleher, Richard D LeDuc, Ryan T Fellers. ProSight Annotator: Complete control and customization of protein entries in UniProt XML files. Proteomics. 2022 Jun;22(11-12):e2100209

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 35286768

View Full Text