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Lumbar disc herniation (LDH) is one of the most common causes of lumbocrural pain. In the past 20 years, the incidence of LDH has increased dramatically. There are many treatments for LDH, including conservative treatment (such as acupuncture and physiotherapy), minimally invasive interventional treatment (such as collagenase chemonucleolysis and radiofrequency ablation) and surgical treatment. The main purpose of this paper is to review the development process and application status of collagenase chemonucleolysis in the treatment of LDH at home and abroad and provide a reference for clinical treatment. © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.


Peng Yuan, Xiaohua Shi, Xuanjun Wei, Zijun Wang, Jiao Mu, Hongxin Zhang. Development process and clinical application of collagenase chemonucleolysis in the treatment of lumbar disc herniation: a narrative review in China. Postgraduate medical journal. 2022 Mar 14

PMID: 35288448

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