α4β7high CD4+ T cells are prone to be infected by HIV-1 and associated with HIV-1 disease progression.

To investigate the characteristics of β7high CD4+ T cells during HIV-1 infection and the relationship between β7high CD4+ T cells and HIV-1 disease progress. This study enrolled 124 HIV-1-infected patients, including 80 treatment naïve patients (TNs), 41 patients who underwent antiretroviral therapy (ARTs), and three long-term no progression patients (LTNPs). Nineteen matched healthy subjects were included as controls (HCs). The characteristics and frequency of β7high CD4+ T cells were analyzed using flow cytometry. An in vitro culture experiment was used to study HIV-1 infection of β7high CD4+ T cells. Real-time polymerase chain reaction was performed to quantify HIV-1 DNA and CA-RNA levels. The frequency of β7high CD4+ T in the peripheral blood was significantly decreased and negatively correlated with disease progression during chronic HIV-1 infection. A large proportion of β7high CD4+ T cells showed Th17 phenotype. Furthermore, β7high CD4+ T cells were preferentially infected by HIV-1 in vitro and in vivo. There were no significant differences of HIV-1 DNA, and CA-RNA levels between β7high CD4+ T and β7low CD4+ T subsets in HIV-1 infected individuals after antiviral treatment. The β7high CD4+ T cells were negatively correlated with disease progression during chronic HIV-1 infection. β7high CD4+ T cells are susceptible to infection with HIV-1 and HIV-1 latent cells. © 2022 British HIV Association.

Citation

Zilaiguli Mijiti, Jin-Wen Song, Yan-Mei Jiao, Lin Gao, Hai-Mei Ma, Xiao-Yan Guo, Qing Zhang, Yun-Tian Guo, Jian-Bing Ding, Shi-Bin Zhang, Fu-Sheng Wang. α4β7high CD4+ T cells are prone to be infected by HIV-1 and associated with HIV-1 disease progression. HIV medicine. 2022 Mar;23 Suppl 1:106-114

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PMID: 35293101

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