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A series of amphipathic poly-β-peptides are designed for intracellular protein delivery. The poly-β-peptides with higher molecular weight and hydrophobic contents exhibit higher protein loading and superior delivery efficiency. The lead material efficiently delivers proteins into cells with reserved bioactivity.


Qianyi Ren, Qi Chen, Lanfang Ren, Chuntao Cao, Runhui Liu, Yiyun Cheng. Amphipathic poly-β-peptides for intracellular protein delivery. Chemical communications (Cambridge, England). 2022 Mar 31;58(27):4320-4323

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PMID: 35293911

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