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Consideration of contact allergen concomitant reactivity, which encompasses cross-reactors, co-reactors, and pseudo cross-reactors, is an important aspect of patient care, yet information on how these terms are differentiated and used in clinical practice is lacking. In this review, we provide definitions of cross-reactors, coreactors, and pseudo cross-reactors and discuss the utility of the American Contact Dermatitis Society Contact Allergen Management Program database cross-reactor groupings. We also discuss limitations to the current categorization of cross-reactivity and recommend incorporating new terms, including "apparent cross-reactor" and "derivative cross-reactor," when classifying cross-reactors. Copyright © 2021 American Contact Dermatitis Society. All Rights Reserved.


Andrew Scheman, Jenna L Ruggiero, Lillian Kerchinsky, Jonathan H Zippin, Matthew Zirwas, Aida Lugo-Somilinos, Sara Hylwa. Contact Allergy Cross-reactions and Thresholds: A Review. Dermatitis : contact, atopic, occupational, drug. 2022 Mar-Apr 01;33(2):106-109

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PMID: 35297589

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