Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma.

Clinical epigenetics 2022 Mar 17

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SWI/SNF complexes are major targets of mutations in cancer. Here, we combined multiple "-omics" methods to assess SWI/SNF composition and aberrations in LUAD. Mutations in lung SWI/SNF subunits were highly recurrent in our LUAD cohort (41.4%), and over 70% of the mutations were predicted to have functional impact. Furthermore, SWI/SNF expression in LUAD suffered an overall repression that could not be explained exclusively by genetic alterations. Finally, SWI/SNF mutations were associated with poorer overall survival in TCGA-LUAD. We propose SWI/SNF-mutant LUAD as a separate clinical subgroup with practical implications. © 2022. The Author(s).

Citation

Paola Peinado, Alvaro Andrades, Marta Cuadros, Maria Isabel Rodriguez, Isabel F Coira, Daniel J Garcia, Maria S Benitez-Cantos, Carlos Cano, Eduardo Zarzuela, Javier Muñoz, Claudia Loidi, Monica Saiz, Pedro P Medina. Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma. Clinical epigenetics. 2022 Mar 17;14(1):42