Vanadium and diabetic dyslipidemia: A systematic review of animal studies.

Diabetic dyslipidemia is caused by hyperglycemia and excessive mobilization of storage lipids, leading to increasing concentrations of triglycerides and total cholesterol. Due to the insulin-mimetic or insulin-enhancer features of vanadium, it has been recognized as a regulator of cell metabolism with hypoglycemic and hypolipidemic properties. The purpose of the current animal systematic review was to evaluate the effect of vanadium administration on diabetic dyslipidemia in diabetic animals. This is, to our knowledge, the first systematic review with the aim of investigating the relationship between vanadium and diabetic dyslipidemia among diabetes induced animals. Searches were performed in PubMed, Scopus, and web of science databases for animal studies examining the effect of vanadium on diabetic dyslipidemia in diabetic animals. Of 124 full-text articles assessed, 48 animal studies were included in the present study with minor risk of bias. The majority of the studies confirmed the beneficial effects of different vanadium compounds in at least one of the parameters of lipid profile, especially regarding triglyceride and total cholesterol. Current findings lend support to assess the long-term effects of different forms and doses of vanadium on lipid profile through well-designed clinical trials. Copyright © 2022 Elsevier GmbH. All rights reserved.

Citation

Faezeh Ghalichi, Alireza Ostadrahimi, Maryam Saghafi-Asl. Vanadium and diabetic dyslipidemia: A systematic review of animal studies. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2022 May;71:126955

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PMID: 35303513

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