Aging impact on amyloid precursor protein neuronal trafficking.

Tatiana Burrinha, Cláudia Guimas Almeida

Current opinion in neurobiology 2022 Apr

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Neurons live a lifetime. Neuronal aging may increase the risk of Alzheimer's disease. How does neuronal membrane trafficking maintain synapse function during aging? In the normal aged brain, intraneuronal beta-amyloid (Aβ) accumulates without Alzheimer's disease mutations or risk variants. However, do changes with neuronal aging potentiate Aβ accumulation? We reviewed the membrane trafficking of the amyloid precursor protein in neurons and highlighted its importance in Aβ production. Importantly, we reviewed the evidence supporting the impact of aging on neuronal membrane trafficking, APP processing, and consequently Aβ production. Dissecting the molecular regulators of APP trafficking during neuronal aging is required to identify strategies to delay synaptic decline and protect from Alzheimer's disease. Copyright © 2022 Elsevier Ltd. All rights reserved.

Citation

Tatiana Burrinha, Cláudia Guimas Almeida. Aging impact on amyloid precursor protein neuronal trafficking. Current opinion in neurobiology. 2022 Apr;73:102524