Oral anticoagulants (NOAC and VKA) in chronic thromboembolic pulmonary hypertension.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2022 Jun

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EXPERT was an international, multicenter, prospective, uncontrolled, non-interventional cohort study in patients with pulmonary hypertension treated with riociguat. Patients were followed for 1-4 years, and the primary outcomes were adverse events (AEs) and serious AEs (SAEs), including embolic/thrombotic and hemorrhagic events. Here we report data on patients with chronic thromboembolic pulmonary hypertension (CTEPH) receiving a vitamin K antagonist (VKA; n = 683) or a non-vitamin K antagonist oral anticoagulant (NOAC; n = 198) at baseline. AEs and SAEs were reported in 438 patients (64.1%) and 257 patients (37.6%), respectively, in the VKA group, and in 135 patients (68.2%) and 74 patients (37.4%) in the NOAC group. Exposure-adjusted hemorrhagic event rates were similar in the two groups, while exposure-adjusted embolic and/or thrombotic event rates were higher in the NOAC group, although the numbers of events were small. Further studies are required to determine the long-term effects of anticoagulation strategies in CTEPH. Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

Marc Humbert, Gérald Simonneau, David Pittrow, Marion Delcroix, Joanna Pepke-Zaba, David Langleben, Lisa M Mielniczuk, Pilar Escribano Subias, Repke J Snijder, Joan A Barberà, Jens Klotsche, Christian Meier, Marius M Hoeper. Oral anticoagulants (NOAC and VKA) in chronic thromboembolic pulmonary hypertension. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2022 Jun;41(6):716-721