Transcriptional expression analysis reveals multiple effects of nonylphenol exposure on scallop immune system.

Qian Liu, Fangshu Li, Wenjuan Liu, Baoyu Huang, Lingling Li, Xiaona Wang, Xiuxiu Sang, Juan Dong, Jilv Ma, Jiwen Chen, Lei Wei, Yaqiong Liu, Meiwei Zhang, Yijing Han, Xiaotong Wang

Fish & shellfish immunology 2022 Apr

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Nonylphenol (NP) is an endocrine disruptor and environmental hormone representing alkylphenol compounds. Marine mollusks are an important source of protein for people worldwide. Many researchers have begun to study the effect of NP on marine mollusks immune system in view of its toxicity; however, the underlying molecular mechanisms require in-depth analysis. In this study, we focused on the transcriptional expression change of immune-related genes and antioxidant enzymes activities variation after NP exposure in a marine bivalve mollusk, Chlamys farreri, to explore the immunomodulatory capacity of NP in marine mollusks. We identified MAVS (Mitochondrial antiviral signaling protein), a key adaptor molecule in the RLR (RIG-I like receptor) pathway, and studied the expression of multiple immune-related genes in response to different concentrations of NP. The key genes involved in RLR/TLR (Toll like receptor) innate immune pathway, apoptosis, and cellular antioxidation mechanism were investigated. Changes in the enzymatic activities of scallop antioxidant enzymes after NP exposure were also examined. The results revealed that the genes expression and the antioxidant enzymes activities show significant changes, thus proving that NP stimulation affects the scallop immune system. Our research results demonstrate the immunomodulatory capacity of NP in marine bivalve mollusks and lay the foundation for further in-depth analysis of the molecular mechanism of NP toxicity. Copyright © 2022 Elsevier Ltd. All rights reserved.

Citation

Qian Liu, Fangshu Li, Wenjuan Liu, Baoyu Huang, Lingling Li, Xiaona Wang, Xiuxiu Sang, Juan Dong, Jilv Ma, Jiwen Chen, Lei Wei, Yaqiong Liu, Meiwei Zhang, Yijing Han, Xiaotong Wang. Transcriptional expression analysis reveals multiple effects of nonylphenol exposure on scallop immune system. Fish & shellfish immunology. 2022 Apr;123:290-297