THE EFFECT OF DIET ENRICHED WITH PYROPHOSPHATE (E450) ON MORPHOLOGICAL CHANGES OF TOOTH GERMS OF MOUSE EMBRYOS.

Inessa I Yakubova, Victor Dosenko, Lesya Tumanovska, Volodymyr Ostrianko, Sergii Tsypan, Yurii Skrypnyk

Wiadomosci lekarskie (Warsaw, Poland : 1960) 2022

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The aim: To reveal the effect of pyrophosphates on the tooth germ structure in the mandible of embryos (17th day of pregnancy) gestated by females, kept on a pyrophosphate-rich diet since 30 days before fertilization to gestation. Materials and methods: The effect of food supplements was studied in «Overload phosphates model». Experiments were carried out on white nonlinear outbred mice with mass 25-28g (n= 40). The females from the control group were fed with standard rodent food, whereas the experimental females were fed with pyrophosphate-enriched food. The material for the morphological study were the mandible of 17-day-old mouse embryos (E-17), which were examined under a microscope with subsequent photofixation. Results: The examination of the mandible of 17-day-old mouse embryos, gestated by females on a pyrophosphate-rich diet, showed morphological changes in tooth germs at the dental follicle development stage. Conclusions: The experimentation revealed that the pyrophosphate excessive intake during dental follicle development leads to early dentinogenesis and oppression of ectodermal structures of tooth germs.

Citation

Inessa I Yakubova, Victor Dosenko, Lesya Tumanovska, Volodymyr Ostrianko, Sergii Tsypan, Yurii Skrypnyk. THE EFFECT OF DIET ENRICHED WITH PYROPHOSPHATE (E450) ON MORPHOLOGICAL CHANGES OF TOOTH GERMS OF MOUSE EMBRYOS. Wiadomosci lekarskie (Warsaw, Poland : 1960). 2022;75(2):410-415