Into the unknown: Diagnosing mysterious brain lesions.

In this inaugural clinicopathological conference, the invited experts discussed the diagnostic approach to central nervous system infections in immunocompromised hosts. The case presented involved a pancreas-kidney transplant recipient with multiple brain abscesses caused by Bartonella henselae. CSF metagenomic next-generation sequencing played a significant role in the diagnosis. Bartonella henselae is a gram-negative zoonotic pathogen that causes cat-scratch disease, which can be transmitted to humans through cat bites or scratches. Symptoms can vary in severity, correlating with the patient's immune status. Visceral organ involvement, ocular involvement, and neurological manifestations have been reported in immunocompromised patients, but brain abscesses are rare. © 2022 Wiley Periodicals LLC.

Citation

Ihab Kassab, Carlos Isada, Marwan M Azar, Nadine Sarsam, Min Jiang, Sandra Camelo-Piragua, Daniel Kaul, Maricar Malinis. Into the unknown: Diagnosing mysterious brain lesions. Transplant infectious disease : an official journal of the Transplantation Society. 2022 Aug;24(4):e13829

Mesh Tags

PMID: 35307917

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