Continuous-flow synthesis of alkyl zinc sulfinates for the direct photofunctionalization of heterocycles.

A sustainable strategy for the alkylation of heterocycles is presented. The protocol relies on the in situ generation and further in-line use of alkyl zinc sulfinates through a continuous-flow system. The environmentally friendly character of the protocol is assured by the use of a green solvent mixture, the presence of a metal free oxidant and low waste generation.

Citation

José Luis Nova-Fernández, Montaña J García, Leonardo Mollari, Gustavo Pascual-Coca, Silvia Cabrera, José Alemán. Continuous-flow synthesis of alkyl zinc sulfinates for the direct photofunctionalization of heterocycles. Chemical communications (Cambridge, England). 2022 Apr 07;58(29):4611-4614

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PMID: 35315862

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