Caloforines A-G, coumarins from the bark of Calophyllum scriblitifolium.

Ai Ogasawara, Ryo Noguchi, Takuya Shigi, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Takahiro Tougan, Toshihiro Horii, A Hamid A Hadi, Hiroshi Morita

Journal of natural medicines 2022 Jun

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Bioactivity-guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A-E (1-5) and two new coumarins, caloforines F and G (6 and 7). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. Caloforines A-F (1-6) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain. © 2022. The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy.

Citation

Ai Ogasawara, Ryo Noguchi, Takuya Shigi, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Takahiro Tougan, Toshihiro Horii, A Hamid A Hadi, Hiroshi Morita. Caloforines A-G, coumarins from the bark of Calophyllum scriblitifolium. Journal of natural medicines. 2022 Jun;76(3):645-653