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Severe mosquito bite allergy (SMBA) is characterized by necrotic skin lesions and systemic symptoms. Chronic active Epstein-Barr virus (EBV) infection, when superimposed with SMBA, is a key driver for catastrophic clinical consequences, such as uncontrolled lymphoproliferation. This interplay is of clinical significance due to its association with hemophagocytic lymphohistiocytosis (HLH) and/or EBV-driven malignancies. Here, we report a case of SMBA that developed in a 14-year-old Hispanic boy that led to fatal secondary HLH. © 2022 Wiley Periodicals LLC.


Elizabeth Dupuy, Ladan Afifi, Steven J Jonas, Carol E Cheng, Marcia Hogeling. A Case of severe mosquito bite allergy complicated by fatal hemophagocytic lymphohistiocytosis. Pediatric dermatology. 2022 May;39(3):443-446

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PMID: 35322460

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