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The origin of life is still one of humankind's great mysteries. At the transition between nonliving and living matter, protocells, initially featureless aggregates of abiotic matter, gain the structure and functions necessary to fulfill the criteria of life. Research addressing protocells as a central element in this transition is diverse and increasingly interdisciplinary. The authors review current protocell concepts and research directions, address milestones, challenges and existing hypotheses in the context of conditions on the early Earth, and provide a concise overview of current protocell research methods. © 2022 The Authors. Small published by Wiley-VCH GmbH.

Citation

Irep Gözen, Elif Senem Köksal, Inga Põldsalu, Lin Xue, Karolina Spustova, Esteban Pedrueza-Villalmanzo, Ruslan Ryskulov, Fanda Meng, Aldo Jesorka. Protocells: Milestones and Recent Advances. Small (Weinheim an der Bergstrasse, Germany). 2022 May;18(18):e2106624

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PMID: 35322554

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