Bookmark
Forward
Asymmetric Synthesis of Pyrrolidines via Oxetane Desymmetrization.
Renwei Zhang, Meng Sun, Qiaolin Yan, Xingbang Lin, Xin Li, Xin Fang, Herman H Y Sung, Ian D Williams, Jianwei Sun
Organic letters 2022 Apr 01Sizes of these terms reflect their relevance to your search.
Asymmetric synthesis of chiral pyrrolidines bearing an all-carbon quaternary stereocenter in the 3-position remains challenging. Herein we report two efficient protocols by means of oxetane desymmetrization, featuring the use of a readily available tert-butylsulfinamide chiral auxiliary and a catalytic system with chiral phosphoric acid as the source of chirality, respectively.
Citation
Renwei Zhang, Meng Sun, Qiaolin Yan, Xingbang Lin, Xin Li, Xin Fang, Herman H Y Sung, Ian D Williams, Jianwei Sun. Asymmetric Synthesis of Pyrrolidines via Oxetane Desymmetrization. Organic letters. 2022 Apr 01;24(12):2359-2364
Mesh Tags
Substances
PMID: 35322664
View Full Text
