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Maintenance of protein homeostasis is crucial for virtually every aspect of eukaryotic biology. The ubiquitin-proteasome system (UPS) represents a highly regulated quality control machinery that protects cells from a variety of stress conditions as well as toxic proteins. A large body of evidence has shown that UPS dysfunction contributes to the pathogenesis of cardiovascular diseases. This review highlights the latest findings regarding the physiological and pathological roles of cullin-RING ubiquitin ligases (CRLs), an essential player in the UPS, in the cardiovascular system. To inspire potential therapeutic invention, factors regulating CRL activities are also discussed.


Stephanie Diaz, Kankan Wang, Benita Sjögren, Xing Liu. Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases. Biomolecules. 2022 Mar 08;12(3)

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PMID: 35327608

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