Roles of Syndecan-4 in cardiac injury and repair.

Faheem Shaik, Michaela J M Balderstone, Samantha Arokiasamy, James R Whiteford

The international journal of biochemistry & cell biology 2022 May

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The heparan sulphate proteoglycan Syndecan-4 belongs to a 4-member family of transmembrane receptors. Genetic deletion of Syndecan-4 in mice causes negligible developmental abnormalities however when challenged these animals show distinct phenotypes. Synedcan-4 is expressed in many cell types in the heart and its expression is elevated in response to cardiac injury and recent studies have suggested roles for Syndecan-4 in repair mechanisms within the damaged heart. The purpose of this review is to explore these biological insights into the role of Syndecan-4 in both the injured heart and later during cardiac repair and remodeling. Copyright © 2022 Elsevier Ltd. All rights reserved.

Citation

Faheem Shaik, Michaela J M Balderstone, Samantha Arokiasamy, James R Whiteford. Roles of Syndecan-4 in cardiac injury and repair. The international journal of biochemistry & cell biology. 2022 May;146:106196