Bioinspired Cobalt-Catalysis Enables Generation of Nucleophilic Radicals from Oxetanes.

Oxetanes are valuable building blocks due to their well-explored propensity to undergo ring-opening reactions with nucleophiles. However, their application as precursors of radical species is still elusive. Herein, we present a bioinspired cobalt-catalysis-based strategy to access unprecedented modes of radical reactivity via oxetane ring-opening. This powerful approach gives access to nucleophilic radicals that engage in reactions with SOMOphiles and low-valent transition metals. Importantly, the regioselectivity of these processes complements known methodologies.

Citation

Aleksandra Potrząsaj, Michał Ociepa, Wojciech Chaładaj, Dorota Gryko. Bioinspired Cobalt-Catalysis Enables Generation of Nucleophilic Radicals from Oxetanes. Organic letters. 2022 Apr 08;24(13):2469-2473

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PMID: 35333537

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